PPARα gene polymorphisms modulate the association between physical activity and cardiometabolic risk.

ABSTRACT:

Background and aims

Habitual physical activity is understood to help prevent type 2 diabetes and atherosclerotic cardiovascular disease via beneficial effects on both metabolism and the vascular system. However, individuals do not have uniform cardiometabolic responses to physical activity. Here we explore the extent to which variation in the proliferator-activated receptor-alpha (PPARα) gene, which modulates carbohydrate and lipid metabolism, vascular function, and inflammation, predicts the overall cardiometabolic risk (CMR) profile of individuals engaging in various levels of physical activity.

Methods and results

917 unrelated, community volunteers (52% female, of Non-Hispanic European ancestry) aged 30-54 years, participated in the cross-sectional study. Subjects were g

SUBMITTER: Halder I 

PROVIDER: S-EPMC4050124 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature