Characterization of the DYX2 locus on chromosome 6p22 with reading disability, language impairment, and IQ.

ABSTRACT: Reading disability (RD) and language impairment (LI) are common neurodevelopmental disorders with moderately strong genetic components and lifelong implications. RD and LI are marked by unexpected difficulty acquiring and processing written and verbal language, respectively, despite adequate opportunity and instruction. RD and LI-and their associated deficits-are complex, multifactorial, and often comorbid. Genetic studies have repeatedly implicated the DYX2 locus, specifically the genes DCDC2 and KIAA0319, in RD, with recent studies suggesting they also influence LI, verbal language, and cognition. Here, we characterize the relationship of the DYX2 locus with RD, LI, and IQ. To accomplish this, we developed a marker panel densely covering the 1.4 Mb DYX2 locus and assessed association wit

SUBMITTER: Eicher JD 

PROVIDER: S-EPMC4053598 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature