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CXC and CC chemokines as angiogenic modulators in nonhaematological tumors.

ABSTRACT: Chemokines are a superfamily of structurally homologous heparin-binding proteins that includes potent inducers and inhibitors of angiogenesis. The imbalance between angiogenic and angiostatic chemokine activities can lead to abnormalities, such as chronic inflammation, dysplastic transformation, and even tumor development and spreading. In this review, we summarize the current literature regarding the role of chemokines as modulators of tumor angiogenesis and their potential role as therapeutic targets in patients with nonhaematological tumors.

SUBMITTER: Santoni M 

PROVIDER: S-EPMC4058128 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature

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CXC and CC chemokines as angiogenic modulators in nonhaematological tumors.

Santoni Matteo M   Bracarda Sergio S   Nabissi Massimo M   Massari Francesco F   Conti Alessandro A   Bria Emilio E   Tortora Giampaolo G   Santoni Giorgio G   Cascinu Stefano S  

BioMed research international 20140529

Chemokines are a superfamily of structurally homologous heparin-binding proteins that includes potent inducers and inhibitors of angiogenesis. The imbalance between angiogenic and angiostatic chemokine activities can lead to abnormalities, such as chronic inflammation, dysplastic transformation, and even tumor development and spreading. In this review, we summarize the current literature regarding the role of chemokines as modulators of tumor angiogenesis and their potential role as therapeutic  ...[more]

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