Interferon-inducible CXC-chemokines are crucial immune modulators and survival predictors in colorectal cancer.

ABSTRACT: Tumor-infiltrating T-cells are strongly associated with prognosis in colorectal cancer, but the mechanisms governing intratumoral lymphocyte recruitment are unclear. We investigated the clinical relevance and functional contribution of interferon-regulated CXC-chemokines CXCL9, CXCL10, and CXCL11, described as T-cells attractants. Their expression was significantly elevated in tumors as compared to normal colon in 163 patients with colon cancer, represented an independent positive predictor of post-operative survival, and was highly significantly correlated with the presence of tumor-infiltrating cytotoxic CD8⁺ T-cells and CD4⁺ T_H1-effector cells. The regulation of chemokine expression was investigated in established cell lines and in tissue explants from r

SUBMITTER: Kistner L 

PROVIDER: S-EPMC5685727 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature