Prevalence and prognostic importance of changes in renal function after mechanical circulatory support.

ABSTRACT:

Background

The long-term durability and prognostic significance of improvement in renal function after mechanical circulatory support (MCS) has yet to be characterized in a large multicenter population. The primary goals of this analysis were to describe serial post-MCS changes in estimated glomerular filtration rate (eGFR) and determine their association with all-cause mortality.

Methods and results

Adult patients enrolled in the Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS) with serial creatinine levels available (n=3363) were studied. Early post-MCS, eGFR improved substantially (median improvement, 48.9%; P<0.001) with 22.3% of the population improving their eGFR by ≥100% within the first few weeks. However, in the majority of patients, th

SUBMITTER: Brisco MA 

PROVIDER: S-EPMC4067252 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature