Lactase non-persistence and milk consumption in Estonia.

ABSTRACT:

Aim

To define the frequency of the C/T-13910 variant associated with lactase persistence/non-persistence trait and to analyze the milk consumption of lactase non-persistent subjects in Estonia.

Methods

We genotyped 355 Estonians by polymerase chain reaction and direct sequencing. Milk consumption was analyzed by a questionnaire, specially developed to analyze milk consumption and abdominal complaints.

Results

The frequency of the genotype of the C/C-13910 (lactase non-persistence) was found to be 24.8% in native Estonians. No other single nucleotide polymorphisms covering the region of 400 bp adjacent to the C/T-13910 variant were found. Lactase non-persistence subjects were found to consume less milk than lactase persistence subjects.

Conclusion

The frequency

SUBMITTER: Lember M 

PROVIDER: S-EPMC4087492 | biostudies-literature | 2006 Dec

REPOSITORIES: biostudies-literature