A functional variant in the CD209 promoter is associated with DQ2-negative celiac disease in the Spanish population.

ABSTRACT:

Aim

To address the role of CD209 in celiac disease (CD) patients. Non-human leukocyte antigen (HLA) genetic factors in CD predisposition are poorly understood, and environmental factors like infectious pathogens may play a role. CD209 is a dendritic and macrophage surface molecule involved in pathogen recognition and immune activation. Recently, a functional variant in the promoter of the CD209 gene (-336A/G) has been shown to affect the transcriptional CD209 activity in vitro and it has been associated with a higher susceptibility to/or severity of infection.

Methods

The study population was composed of two case-control cohorts of 103 and 386 CD patients and 312 y 419 healthy controls as well as a panel of 257 celiac families. Genotyping for the -336A/G CD209 promoter polym

SUBMITTER: Nunez C 

PROVIDER: S-EPMC4087754 | biostudies-literature | 2006 Jul

REPOSITORIES: biostudies-literature