Haptoglobin phenotype and abnormal uterine artery Doppler in a racially diverse cohort.

ABSTRACT:

Objective

The anti-oxidant and proangiogenic protein haptoglobin (Hp) is believed to be important for implantation and pregnancy, although its specific role is not known. The three phenotypes (1-1, 2-1 and 2-2) differ in structure and function. Hp 2-2 is associated with increased vascular stiffness in other populations. We examined whether Hp phenotype is associated with abnormal uterine artery Doppler (UAD) in pregnancy.

Methods

We conducted a secondary analysis of a preeclampsia prediction cohort nested within a larger placebo-controlled randomized clinical trial of antioxidants for prevention of preeclampsia. We determined Hp phenotype in 2184 women who completed UAD assessments at 17 weeks gestation. Women with notching were re-evaluated for persistent notching at 24 wee

SUBMITTER: Weissgerber TL 

PROVIDER: S-EPMC4096612 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature