Longitudinal changes in airway remodeling and air trapping in severe asthma.

ABSTRACT:

Rationale and objectives

Previous cross-sectional studies have demonstrated that airway wall thickness and air trapping are greater in subjects with severe asthma than in those with mild-to-moderate asthma. However, a better understanding of how airway remodeling and lung density change over time is needed. This study aimed to evaluate predictors of airway wall remodeling and change in lung function and lung density over time in severe asthma.

Materials and methods

Phenotypic characterization and quantitative multidetector-row computed tomography (MDCT) of the chest were performed at baseline and ∼2.6 years later in 38 participants with asthma (severe n = 24 and mild-to-moderate n = 14) and nine normal controls from the Severe Asthma Research Program.

Results

Subjects

SUBMITTER: Witt CA 

PROVIDER: S-EPMC4100072 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature