IL-33 promotes airway remodeling in pediatric patients with severe steroid-resistant asthma.

ABSTRACT:

Background

TH2 cytokines are not responsible for the ongoing symptoms and pathology in children with severe therapy-resistant asthma (STRA). IL-33 induces airway hyperresponsiveness, but its role in airway remodeling and steroid resistance is unknown.

Objective

We sought to investigate the relationship between IL-33 and airway remodeling in pediatric patients with STRA.

Methods

IL-33 levels were quantified in neonatal mice given inhaled house dust mite (HDM), and the effect of blocking IL-13 on remodeling and IL-33 levels was assessed. HDM-induced allergic airways disease (AAD) in neonatal ST2(-/-) mice lacking the IL-33 receptor was assessed, together with collagen production after IL-33 administration. The effect of steroid therapy on IL-33 levels in patients with n

SUBMITTER: Saglani S 

PROVIDER: S-EPMC4218948 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature