Benefits and harms of computed tomography lung cancer screening strategies: a comparative modeling study for the U.S. Preventive Services Task Force.

ABSTRACT:

Background

The optimum screening policy for lung cancer is unknown.

Objective

To identify efficient computed tomography (CT) screening scenarios in which relatively more lung cancer deaths are averted for fewer CT screening examinations.

Design

Comparative modeling study using 5 independent models.

Data sources

The National Lung Screening Trial; the Prostate, Lung, Colorectal, and Ovarian Cancer Screening trial; the Surveillance, Epidemiology, and End Results program; and the U.S. Smoking History Generator.

Target population

U.S. cohort born in 1950.

Time horizon

Cohort followed from ages 45 to 90 years.

Perspective

Societal.

Intervention

576 scenarios with varying eligibility criteria (age, pack-years of smoking, years since quittin

SUBMITTER: de Koning HJ 

PROVIDER: S-EPMC4116741 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature