R PheWAS: data analysis and plotting tools for phenome-wide association studies in the R environment.

ABSTRACT:

Unlabelled

Phenome-wide association studies (PheWAS) have been used to replicate known genetic associations and discover new phenotype associations for genetic variants. This PheWAS implementation allows users to translate ICD-9 codes to PheWAS case and control groups, perform analyses using these and/or other phenotypes with covariate adjustments and plot the results. We demonstrate the methods by replicating a PheWAS on rs3135388 (near HLA-DRB, associated with multiple sclerosis) and performing a novel PheWAS using an individual's maximum white blood cell count (WBC) as a continuous measure. Our results for rs3135388 replicate known associations with more significant results than the original study on the same dataset. Our PheWAS of WBC found expected results, including associati

SUBMITTER: Carroll RJ 

PROVIDER: S-EPMC4133579 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature