Ontology highlight
ABSTRACT:
SUBMITTER: Lu P
PROVIDER: S-EPMC4134323 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Lu Peilong P Bai Xiao-Chen XC Ma Dan D Xie Tian T Yan Chuangye C Sun Linfeng L Yang Guanghui G Zhao Yanyu Y Zhou Rui R Scheres Sjors H W SHW Shi Yigong Y
Nature 20140629 7513
The γ-secretase complex, comprising presenilin 1 (PS1), PEN-2, APH-1 and nicastrin, is a membrane-embedded protease that controls a number of important cellular functions through substrate cleavage. Aberrant cleavage of the amyloid precursor protein (APP) results in aggregation of amyloid-β, which accumulates in the brain and consequently causes Alzheimer's disease. Here we report the three-dimensional structure of an intact human γ-secretase complex at 4.5 Å resolution, determined by cryo-elect ...[more]