In vitro efficacy of brincidofovir against variola virus.
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ABSTRACT:
SUBMITTER: Olson VA
PROVIDER: S-EPMC4135866 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Publications
In vitro efficacy of brincidofovir against variola virus.
Olson Victoria A VA Smith Scott K SK Foster Scott S Li Yu Y Lanier E Randall ER Gates Irina I Trost Lawrence C LC Damon Inger K IK
Antimicrobial agents and chemotherapy 20140623 9
Brincidofovir (CMX001), a lipid conjugate of the acyclic nucleotide phosphonate cidofovir, is under development for smallpox treatment using "the Animal Rule," established by the FDA in 2002. Brincidofovir reduces mortality caused by orthopoxvirus infection in animal models. Compared to cidofovir, brincidofovir has increased potency, is administered orally, and shows no evidence of nephrotoxicity. Here we report that the brincidofovir half-maximal effective concentration (EC50) against five vari ...[more]
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