Ontology highlight
ABSTRACT:
SUBMITTER: Banerji S
PROVIDER: S-EPMC4148686 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Banerji Shantanu S Cibulskis Kristian K Rangel-Escareno Claudia C Brown Kristin K KK Carter Scott L SL Frederick Abbie M AM Lawrence Michael S MS Sivachenko Andrey Y AY Sougnez Carrie C Zou Lihua L Cortes Maria L ML Fernandez-Lopez Juan C JC Peng Shouyong S Ardlie Kristin G KG Auclair Daniel D Bautista-Piña Veronica V Duke Fujiko F Francis Joshua J Jung Joonil J Maffuz-Aziz Antonio A Onofrio Robert C RC Parkin Melissa M Pho Nam H NH Quintanar-Jurado Valeria V Ramos Alex H AH Rebollar-Vega Rosa R Rodriguez-Cuevas Sergio S Romero-Cordoba Sandra L SL Schumacher Steven E SE Stransky Nicolas N Thompson Kristin M KM Uribe-Figueroa Laura L Baselga Jose J Beroukhim Rameen R Polyak Kornelia K Sgroi Dennis C DC Richardson Andrea L AL Jimenez-Sanchez Gerardo G Lander Eric S ES Gabriel Stacey B SB Garraway Levi A LA Golub Todd R TR Melendez-Zajgla Jorge J Toker Alex A Getz Gad G Hidalgo-Miranda Alfredo A Meyerson Matthew M
Nature 20120620 7403
Breast carcinoma is the leading cause of cancer-related mortality in women worldwide, with an estimated 1.38 million new cases and 458,000 deaths in 2008 alone. This malignancy represents a heterogeneous group of tumours with characteristic molecular features, prognosis and responses to available therapy. Recurrent somatic alterations in breast cancer have been described, including mutations and copy number alterations, notably ERBB2 amplifications, the first successful therapy target defined by ...[more]