Patients with schizophrenia demonstrate reduced cortical sensitivity to auditory oddball regularities.

ABSTRACT:

Background

Individuals with schizophrenia demonstrate deficits in context processing. These deficits can be characterized by examining the influence of auditory context on ERP responses to rare target tones. Previous studies demonstrate that target ERP deficits in schizophrenia depend on the number of non-targets that precede the target ERP. Our goal was to extend these findings by examining whether patients with schizophrenia demonstrate a reduced sensitivity to subtle differences in the auditory context preceding rare target stimuli, as quantified by Itti and Baldi's Bayesian prediction error model.

Methods

Cortical responses to auditory oddball tones were measured within 59 individuals with schizophrenia (SZ) and 59 controls (HC). Individual trial amplitudes were estimate

SUBMITTER: Bridwell DA 

PROVIDER: S-EPMC4152401 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature