Ontology highlight
ABSTRACT:
SUBMITTER: Witkin KL
PROVIDER: S-EPMC415636 | biostudies-literature | 2004 May
REPOSITORIES: biostudies-literature
Witkin Keren L KL Collins Kathleen K
Genes & development 20040506 10
Many proteins have been implicated in the physiological function of telomerase, but specific roles of telomerase-associated proteins other than telomerase reverse transcriptase (TERT) remain ambiguous. To gain a more comprehensive understanding of catalytically active enzyme composition, we performed affinity purification of epitope-tagged, endogenously assembled Tetrahymena telomerase. We identified and cloned genes encoding four telomerase proteins in addition to TERT. We demonstrate that both ...[more]