Low-density lipoprotein-mediated delivery of docosahexaenoic acid selectively kills murine liver cancer cells.

ABSTRACT:

Aim

The natural omega-3 polyunsaturated fatty acid, docosahexaenoic acid (DHA), has recently been credited for possessing anticancer properties. Herein, we investigate the cytotoxic actions of DHA-loaded low-density lipoprotein (LDL) nanoparticles in normal and liver cancer cells.

Materials & methods

LDL-DHA nanoparticles were prepared and subjected to extensive biophysical characterization. The therapeutic utility of LDL-DHA nanoparticles was evaluated in normal and malignant murine hepatocyte cell lines, TIB-73 and TIB-75, respectively.

Results & discussion

The engineered LDL-DHA nanoparticles possessed enhanced physical and oxidative stabilities over native LDL and free DHA. Dose-response studies showed that therapeutic doses of LDL-DHA nanoparticles that completel

SUBMITTER: Reynolds L 

PROVIDER: S-EPMC4156561 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature