Lysine propionylation is a prevalent post-translational modification in Thermus thermophilus.

ABSTRACT: Recent studies of protein post-translational modifications revealed that various types of lysine acylation occur in eukaryotic and bacterial proteins. Lysine propionylation, a newly discovered type of acylation, occurs in several proteins, including some histones. In this study, we identified 361 propionylation sites in 183 mid-exponential phase and late stationary phase proteins from Thermus thermophilus HB8, an extremely thermophilic eubacterium. Functional classification of the propionylproteins revealed that the number of propionylation sites in metabolic enzymes increased in late stationary phase, irrespective of protein abundance. The propionylation sites on proteins expressed in mid-exponential and late stationary phases partially overlapped. Furthermore, amino acid frequencies in t

SUBMITTER: Okanishi H 

PROVIDER: S-EPMC4159656 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature