Diagnosis and management of Marchiafava-Bignami disease: a review of CT/MRI confirmed cases.

ABSTRACT:

Objective

Marchiafava-Bignami disease (MBD) is a rare condition mainly associated with alcoholism, although it may be mimicked by several other disorders that cause corpus callosum lesions. Our objective was to identify helpful features for differential diagnosis and assess whether any treatment can be recommended.

Methods

We reviewed 122 reports containing data on 153 subjects with confirmed MBD that was associated with either alcoholism or malnutrition, and 20 reports with data on 53 subjects with conditions mimicking MBD. All the cases had been verified antemortem by brain imaging. Unconditional logistic regression was used to demonstrate factors that were associated with the outcome of MBD.

Results

The mimicking conditions were differentiated from MBD by the occur

SUBMITTER: Hillbom M 

PROVIDER: S-EPMC4160728 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature