Biologically active substances-enriched diet regulates gonadotrope cell activation pathway in liver of adult and old rats.

ABSTRACT: According to the Hippocrates' theorem "Let food be your medicine and medicine be your food", dietary interventions may induce changes in the metabolic and inflammatory state by modulating the expression of important genes involved in the chronic disorders. The aim of the present study was to evaluate the influence of long-term (14 months) use of biologically active substances-enriched diet (BASE-diet) on transcriptomic profile of rats' liver. The experiment was conducted on 36 Sprague-Dawley rats divided into two experimental groups (fed with control or BASE-diet, both n = 18). Control diet was a semi-synthetic diet formulated according to the nutritional requirements for laboratory animals. The BASE-diet was enriched with a mixture of polyphenolic compounds, β-carotene, probiotics, and n-

SUBMITTER: Oszkiel H 

PROVIDER: S-EPMC4172640 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature