Dataset Information

A prospective study of quality of life in patients undergoing pelvic exenteration: interim results.

ABSTRACT:

Objective

Little prospective data exist on quality of life (QOL) after pelvic exenteration (PE). This ongoing study prospectively examines the QOL changes following this radical procedure using a comprehensive battery of psychological instruments.

Methods

Since 2005, enrolled patients were interviewed (EORTC QLQ-C30, EORTC QLQ-CR38, EORTC QLQ-BLM30, BFI, BPI-SF, IADL, CES-D, IES-R) preoperatively and at 3, 6, and 12 months after PE for physical/psychological symptoms. Data were examined using repeated measure ANOVA.

Results

Sixteen women (3 anterior, 1 posterior, and 12 total PEs), with more than 1 year of follow-up, completed all scheduled interviews. Median age was 58 years (range, 28-76 years). Overall QOL (F = 6.3, p < 0.02), ability to perform instrumental daily activities (F = 6.8, p < 0.02), body image (F = 11.9, p < 0.00), and sexual function (F = 8.0, p < 0.01) all declined at 3 months but were near baseline by 12 months after PE. Although, overall, physical function followed a similar trend (F = 14.8, p < 0.00), it did not return to baseline. At the 12-month interview, patients reported increased gastrointestinal symptoms (F = 8.9, p < 0.01) but significantly less stress-related ideation (F = 6.1, p < 0.03) compared to baseline. Pain levels did not change significantly during the study period (F = 0.4, p < 0.74).

Conclusions

Although patients report lingering gastrointestinal symptoms and some persistent decline in physical function after PE, most adjust well, returning to almost baseline functioning within a year. Providers can counsel patients that many, though not all, symptoms in the first 3 months following exenteration are likely to improve as they adapt to their changed health status. These preliminary results await confirmation of a larger analysis.

SUBMITTER: Rezk YA

PROVIDER: S-EPMC4174356 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature

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Publications

A prospective study of quality of life in patients undergoing pelvic exenteration: interim results.

Rezk Youssef A YA Hurley Karen E KE Carter Jeanne J Dao Fanny F Bochner Bernard H BH Aubey Janice J JJ Caceres Aileen A Einstein M Heather MH Abu-Rustum Nadeem R NR Barakat Richard R RR Makker Vicky V Chi Dennis S DS

Gynecologic oncology 20121009 2

<h4>Objective</h4>Little prospective data exist on quality of life (QOL) after pelvic exenteration (PE). This ongoing study prospectively examines the QOL changes following this radical procedure using a comprehensive battery of psychological instruments.<h4>Methods</h4>Since 2005, enrolled patients were interviewed (EORTC QLQ-C30, EORTC QLQ-CR38, EORTC QLQ-BLM30, BFI, BPI-SF, IADL, CES-D, IES-R) preoperatively and at 3, 6, and 12 months after PE for physical/psychological symptoms. Data were ex ...[more]

PMID: 23063761

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Dataset Information

A prospective study of quality of life in patients undergoing pelvic exenteration: interim results.

Objective

Methods

Results

Conclusions

Publications

A prospective study of quality of life in patients undergoing pelvic exenteration: interim results.

Similar Datasets

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