Ontology highlight
ABSTRACT:
SUBMITTER: Fouquerel E
PROVIDER: S-EPMC4177344 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Cell reports 20140915 6
ARTD1 (PARP1) is a key enzyme involved in DNA repair through the synthesis of poly(ADP-ribose) (PAR) in response to strand breaks, and it plays an important role in cell death following excessive DNA damage. ARTD1-induced cell death is associated with NAD(+) depletion and ATP loss; however, the molecular mechanism of ARTD1-mediated energy collapse remains elusive. Using real-time metabolic measurements, we compared the effects of ARTD1 activation and direct NAD(+) depletion. We found that ARTD1- ...[more]