Variations in body weight, food intake and body composition after long-term high-fat diet feeding in C57BL/6J mice.

ABSTRACT: To investigate the variations in body weight, food intake, and body composition of both male and female C57BL/6J mice during a diet-induced obesity model with high-fat diet (HFD) feeding.Mice were individually housed and fed ad libitum either a low-fat diet (LFD, 10% calories from fat; n?=?15 male, n?=?15 female) or HFD (45% calories from fat; n?=?277 male, n?=?278 female) from 8 to 43 weeks of age. Body weight, food intake, and body composition were routinely measured.Body weight was significantly increased with HFD (vs. LFD) in males from week 14 (P?=?0.0221) and in females from week 27 (P?=?0.0076). Fat mass and fat-free mass of all groups were significantly increased over time (all P?

SUBMITTER: Yang Y 

PROVIDER: S-EPMC4180788 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature