Activation of FGF-23 mediated vitamin D degradative pathways by cholecalciferol.

ABSTRACT:

Context

The optimal circulating concentration of 25(OH) vitamin D is controversial.

Objective

The aim was to investigate if FGF-23 and 24,25(OH)2D can guide cholecalciferol replacement.

Design

Oral cholecalciferol (10,000 IU weekly) administered to subjects with 25(OH)D levels < 20 ηg/mL and eGFR > 60 mL/min/1.73 m(2) (n = 25), chronic kidney disease (CKD) (n = 27), or end stage renal disease (ESRD) (n = 14).

Setting

The study was conducted at the Veterans Affairs clinics.

Main outcome measure

Serum FGF-23, PTH, 25(OH)D, 1,25(OH)2D, 24,25(OH)2D, calcium, and phosphorous concentrations, and urinary excretion of calcium and phosphorus at baseline and after 8 weeks of treatment.

Results

Cholecalciferol treatment increased concentrations of serum 25(O

SUBMITTER: Alshayeb H 

PROVIDER: S-EPMC4184071 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature