Genome-wide scan of 29,141 African Americans finds no evidence of directional selection since admixture.

ABSTRACT: The extent of recent selection in admixed populations is currently an unresolved question. We scanned the genomes of 29,141 African Americans and failed to find any genome-wide-significant deviations in local ancestry, indicating no evidence of selection influencing ancestry after admixture. A recent analysis of data from 1,890 African Americans reported that there was evidence of selection in African Americans after their ancestors left Africa, both before and after admixture. Selection after admixture was reported on the basis of deviations in local ancestry, and selection before admixture was reported on the basis of allele-frequency differences between African Americans and African populations. The local-ancestry deviations reported by the previous study did not replicate in our very l

SUBMITTER: Bhatia G 

PROVIDER: S-EPMC4185117 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature