Homology modeling and comparative profiling of superoxide dismutase among extremophiles: exiguobacterium as a model organism.

ABSTRACT: Superoxide dismutase (SOD), a well known antioxidant enzyme, is known to exert its presence across bacteria to humans. Apart from their well-known antioxidant defense mechanisms, their association with various extremophiles in response to various stress conditions is poorly understood. Here, we have discussed the conservation and the prevalence of SODs among 21 representative extremophiles. A systematic investigation of aligned amino acid sequences of SOD from all the selected extremophiles revealed a consensus motif D-[VLE]-[FW]-E-H-[AS]-Y-[YM]. To computationally predict the correlation of SOD with the various stress conditions encountered by these extremophiles, Exiguobacterium was selected as a model organism which is known to survive under various adverse extremophilic conditions. Int

SUBMITTER: Pathak R 

PROVIDER: S-EPMC4186928 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature