Src regulates sequence-dependent beta-2 adrenergic receptor recycling via cortactin phosphorylation.

ABSTRACT: The recycling of internalized signaling receptors, which has direct functional consequences, is subject to multiple sequence and biochemical requirements. Why signaling receptors recycle via a specialized pathway, unlike many other proteins that recycle by bulk, is a fundamental unanswered question. Here, we show that these specialized pathways allow selective control of signaling receptor recycling by heterologous signaling. Using assays to visualize receptor recycling in living cells, we show that the recycling of the beta-2 adrenergic receptor (B2AR), a prototypic signaling receptor, is regulated by Src family kinases. The target of Src is cortactin, an essential factor for B2AR sorting into specialized recycling microdomains on the endosome. Phosphorylation of a single cortactin residu

SUBMITTER: Vistein R 

PROVIDER: S-EPMC4205176 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature