Moderate hypoxia potentiates interleukin-1β production in activated human macrophages.

ABSTRACT:

Rationale

Inflammation drives atherogenesis. Animal and human studies have implicated interleukin-1β (IL-1β) in this disease. Moderate hypoxia, a condition that prevails in the atherosclerotic plaque, may conspire with inflammation and contribute to the evolution and complications of atherosclerosis through mechanisms that remain incompletely understood.

Objective

This study investigated the links between hypoxia and inflammation by testing the hypothesis that moderate hypoxia modulates IL-1β production in activated human macrophages.

Methods and results

Our results demonstrated that hypoxia enhances pro-IL-1β protein, but not mRNA, expression in lipopolysaccharide-stimulated human macrophages. We show that hypoxia limits the selective targeting of pro-IL-1β to autoph

SUBMITTER: Folco EJ 

PROVIDER: S-EPMC4209192 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature