Promoter hypermethylation of the phosphatase DUSP22 mediates PKA-dependent TAU phosphorylation and CREB activation in Alzheimer's disease.
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ABSTRACT:
SUBMITTER: Sanchez-Mut JV
PROVIDER: S-EPMC4233982 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Publications
Promoter hypermethylation of the phosphatase DUSP22 mediates PKA-dependent TAU phosphorylation and CREB activation in Alzheimer's disease.
Sanchez-Mut Jose Vicente JV Aso Ester E Heyn Holger H Matsuda Tadashi T Bock Christoph C Ferrer Isidre I Esteller Manel M
Hippocampus 20140128 4
Genetic screening in Alzheimer's disease (AD) has identified only a handful of genes that are mutated in the disorder. Thus, for a very large proportion of patients, the biology of their disease is poorly understood. Epigenetic alterations may provide an explanation in these cases. Using DNA methylation profiles of human hippocampus from controls and patients, we have identified the presence of promoter hypermethylation of the dual-specificity phosphatase 22 (DUSP22) gene in AD. DUSP22 is a like ...[more]
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