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ABSTRACT: Objective
To assess the efficacy of a chlorhexidine-impregnated dressing for prevention of central venous catheter-related colonization and catheter-related bloodstream infection using meta-analysis.Data sources
Multiple computerized database searches supplemented by manual searches including relevant conference proceedings.Study selection
Randomized controlled trials evaluating the efficacy of a chlorhexidine-impregnated dressing compared with conventional dressings for prevention of catheter colonization and catheter-related bloodstream infection.Data extraction
Data were extracted on patient and catheter characteristics and outcomes.Data synthesis
Nine randomized controlled trials met the inclusion criteria. Use of a chlorhexidine-impregnated dressing resulted in a reduced prevalence of catheter-related bloodstream infection (random effects relative risk, 0.60; 95% CI, 0.41-0.88, p = 0.009). The prevalence of catheter colonization was also markedly reduced in the chlorhexidine-impregnated dressing group (random effects relative risk, 0.52; 95% CI, 0.43-0.64; p < 0.001). There was significant benefit for prevention of catheter colonization and catheter-related bloodstream infection, including arterial catheters used for hemodynamic monitoring. Other than in low birth weight infants, adverse effects were rare and minor.Conclusions
Our analysis shows that a chlorhexidine-impregnated dressing is beneficial in preventing catheter colonization and, more importantly, catheter-related bloodstream infection and warrants routine use in patients at high risk of catheter-related bloodstream infection and central venous catheter or arterial catheter colonization.
SUBMITTER: Safdar N
PROVIDER: S-EPMC4258905 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Safdar Nasia N O'Horo John C JC Ghufran Aiman A Bearden Allison A Didier Maria Eugenia ME Chateau Dan D Maki Dennis G DG
Critical care medicine 20140701 7
<h4>Objective</h4>To assess the efficacy of a chlorhexidine-impregnated dressing for prevention of central venous catheter-related colonization and catheter-related bloodstream infection using meta-analysis.<h4>Data sources</h4>Multiple computerized database searches supplemented by manual searches including relevant conference proceedings.<h4>Study selection</h4>Randomized controlled trials evaluating the efficacy of a chlorhexidine-impregnated dressing compared with conventional dressings for ...[more]