Ontology highlight
ABSTRACT:
SUBMITTER: Cordin O
PROVIDER: S-EPMC4267655 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Nucleic acids research 20141126 22
RNA helicases are essential for virtually all cellular processes, however, their regulation is poorly understood. The activities of eight RNA helicases are required for pre-mRNA splicing. Amongst these, Brr2p is unusual in having two helicase modules, of which only the amino-terminal helicase domain appears to be catalytically active. Using genetic and biochemical approaches, we investigated interaction of the carboxy-terminal helicase module, in particular the carboxy-terminal Sec63-2 domain, w ...[more]