Protective Effects of Lithospermum erythrorhizon Against Cerulein-Induced Acute Pancreatitis.

ABSTRACT:

Objectives

We aimed to evaluate the anti-inflammatory and inhibitory effects of Lithospermum erythrorhizon (LE) on cerulein-induced acute pancreatitis (AP) in a mouse model.

Methods

Acute pancreatitis was induced via intraperitoneal injection of cerulein (50 μg/kg) every hour for 6 times. In the LE, water extract (100, 250, or 500 mg/kg) was administered intraperitoneally 1 hour before the first injection of cerulein. Six hours after AP, blood, the pancreas, and the lung were harvested for further examination. In addition, pancreatic acinar cells were isolated using a collagenase method, and then, we investigated the acinar cell viability and cytokine productions.

Results

Treatment with LE reduced pancreatic damage and AP-associated lung injury and attenuated the seve

SUBMITTER: Choi SB 

PROVIDER: S-EPMC4272226 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature