Force-induced dynamical properties of multiple cytoskeletal filaments are distinct from that of single filaments.

ABSTRACT: How cytoskeletal filaments collectively undergo growth and shrinkage is an intriguing question. Collective properties of multiple bio-filaments (actin or microtubules) undergoing hydrolysis have not been studied extensively earlier within simple theoretical frameworks. In this paper, we study the collective dynamical properties of multiple filaments under force, and demonstrate the distinct properties of a multi-filament system in comparison to a single filament. Comparing stochastic simulation results with recent experimental data, we show that multi-filament collective catastrophes are slower than catastrophes of single filaments. Our study also shows further distinctions as follows: (i) force-dependence of the cap-size distribution of multiple filaments are quantitatively different from

SUBMITTER: Das D 

PROVIDER: S-EPMC4273989 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature