Responding to vaccine safety signals during pandemic influenza: a modeling study.

ABSTRACT:

Background

Managing emerging vaccine safety signals during an influenza pandemic is challenging. Federal regulators must balance vaccine risks against benefits while maintaining public confidence in the public health system.

Methods

We developed a multi-criteria decision analysis model to explore regulatory decision-making in the context of emerging vaccine safety signals during a pandemic. We simulated vaccine safety surveillance system capabilities and used an age-structured compartmental model to develop potential pandemic scenarios. We used an expert-derived multi-attribute utility function to evaluate potential regulatory responses by combining four outcome measures into a single measure of interest: 1) expected vaccination benefit from averted influenza; 2) expected va

SUBMITTER: Maro JC 

PROVIDER: S-EPMC4275236 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature