Bioactive indole alkaloids isolated from Alstonia angustifolia.

ABSTRACT: Bioassay-guided fractionation was conducted on a CHCl₃-soluble extract of the stem bark of Alstonia angustifolia (Apocynaceae) collected in Vietnam using the HT-29 human colon cancer cell line, and led to the isolation of a new sarpagine-type indole alkaloid (1), together with nine known alkaloids, including four macroline-derived alkaloids (2-5), a sarpagine-type alkaloid (6), and four macroline-pleiocarpamine bisindole alkaloids (7-10). The structure of the new compound (1) was determined on the basis of spectroscopic data interpretation. Compounds 1-10 were evaluated in vitro for their NF-κB (p65) inhibitory activity against the Hela cells in an ELISA assay. The new sarpagine alkaloid, N(4)-methyltalpinine (1</

SUBMITTER: Pan L 

PROVIDER: S-EPMC4287998 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature