Estrogen independent gene expression defines clinically relevant subgroups of estrogen receptor positive breast cancer.

ABSTRACT:

Background

Human breast cancer represents a significantly heterogeneous disease. Global gene expression profiling measurements have been used to classify tumors into multiple molecular subtypes. The capacity to define subtypes of breast tumors provides a framework to enable improved understanding of the mechanisms of breast oncogenesis, as well as to provide opportunities for improved therapeutic intervention in patients.

Methods

We used publicly available gene expression profiling data to identify 'estrogen independent' genes in estrogen receptor alpha (ER+) breast tumors, and subsequently identified 6 subgroups of ER+breast tumors.

Results

Each of the 6 identified subgroups exhibited distinct clinical behaviors and biology. Patients whose tumors comprised subgroups

SUBMITTER: Hallett RM 

PROVIDER: S-EPMC4289221 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature