Two-year outcomes in initial survivors with acute liver failure: results from a prospective, multicentre study.

ABSTRACT:

Background & aims

The long-term clinical outcomes in initial survivors with acute liver failure (ALF) are not well known. The aim of this study was to provide an overview of the 2-year clinical outcomes among initial survivors and liver transplant (LT) recipients that were alive 3 weeks after enrolment in the Acute Liver Failure Study Group (ALFSG).

Methods

Outcomes in adult ALFSG patients that were enrolled between 1998 and 2010 were reviewed.

Results

Two-year patient survival was significantly higher in the 262 LT recipients (92.4%) compared to the 306 acetaminophen (APAP) spontaneous survivors (SS) (89.5%) and 200 non-APAP SS (75.5%) (P < 0.0001). The causes of death were similar in the three groups but the time to death was significantly longer in the LT recipient

SUBMITTER: Fontana RJ 

PROVIDER: S-EPMC4291312 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature