Renal xenobiotic transporter expression is altered in multiple experimental models of nonalcoholic steatohepatitis.

ABSTRACT: Nonalcoholic fatty liver disease is the most common chronic liver disease, which can progress to nonalcoholic steatohepatitis (NASH). Previous investigations demonstrated alterations in the expression and activity of hepatic drug transporters in NASH. Moreover, studies using rodent models of cholestasis suggest that compensatory changes in kidney transporter expression occur to facilitate renal excretion during states of hepatic stress; however, little information is currently known regarding extrahepatic regulation of drug transporters in NASH. The purpose of the current study was to investigate the possibility of renal drug transporter regulation in NASH across multiple experimental rodent models. Both rat and mouse NASH models were used in this investigation and include: the methionine

SUBMITTER: Canet MJ 

PROVIDER: S-EPMC4293398 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature