Database screening of herbal monomers regulating autophagy by constructing a "disease-gene-drug" network.

ABSTRACT:

Background

Studies suggest an important role of autophagy as a target for cancer therapy. We constructed a "disease-gene-drug" network using the modular approach of bioinformatics and screened herbal monomers demonstrating functions related to autophagy regulation.

Methods

Based on the microarray results of the gene expression omnibus (GEO) database (GSE2435 and GSE31040, starvation-induced autophagy model), we used the human protein reference database (HPRD) to obtain the protein-protein interaction (PPI) network. In addition, we used the CFinder software to identify several functional modules, performed gene ontology-biological process (GO-BP) functional enrichment analysis using the DAVID software, constructed a herbal monomer-module gene regulatory network using literatu

SUBMITTER: Hao C 

PROVIDER: S-EPMC4295301 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature