PharmOmics: A species- and tissue-specific drug signature database and gene-network-based drug repositioning tool.

ABSTRACT: Drug development has been hampered by a high failure rate in clinical trials due to our incomplete understanding of drug functions across organs and species. Therefore, elucidating species- and tissue-specific drug functions can provide insights into therapeutic efficacy, potential adverse effects, and interspecies differences necessary for effective translational medicine. Here, we present PharmOmics, a drug knowledgebase and analytical tool that is hosted on an interactive web server. Using tissue- and species-specific transcriptome data from human, mouse, and rat curated from different databases, we implemented a gene-network-based approach for drug repositioning. We demonstrate the potential of PharmOmics to retrieve known therapeutic drugs and identify drugs with tissue toxicity using

SUBMITTER: Chen YW 

PROVIDER: S-EPMC8957031 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature