Reconstructing genome-wide protein-protein interaction networks using multiple strategies with homologous mapping.

ABSTRACT:

Background

One of the crucial steps toward understanding the biological functions of a cellular system is to investigate protein-protein interaction (PPI) networks. As an increasing number of reliable PPIs become available, there is a growing need for discovering PPIs to reconstruct PPI networks of interesting organisms. Some interolog-based methods and homologous PPI families have been proposed for predicting PPIs from the known PPIs of source organisms.

Results

Here, we propose a multiple-strategy scoring method to identify reliable PPIs for reconstructing the mouse PPI network from two well-known organisms: human and fly. We firstly identified the PPI candidates of target organisms based on homologous PPIs, sharing significant sequence similarities (joint E-value ≤ 1 × 10

SUBMITTER: Lo YS 

PROVIDER: S-EPMC4300222 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature