Project description:Hereditary Angioedema (HAE) due to C1-inhibitor deficiency is a lifelong illness characterized by recurrent acute attacks of localized edema. Next to the identified role of dys-regulation in the kallikrein/bradykinin pathway at endothelial cell level, the involvement of circulating leucocytes (PBMC) in acute attacks is not yet clarified. To gain further insight into this process, we performed a PBMC microarray gene expression analysis on RNA isolated from patients with HAE comparing the transcriptome profile of acute attack with the remission phase.