Association between male infertility and either the +331G/A or the progins polymorphism of the progesterone receptor gene in a Chinese population.

ABSTRACT:

Background

Progesterone has been suggested to contribute to the regulation of spermatogenesis and to facilitate the production of viable sperm. Investigations have showed that polymorphism of progesterone receptor (PGR) is associated with some diseases.

Objective

To analyze the potential relationship between male infertility and the +331G/A and progins polymorphisms of PGR gene.

Materials and methods

The cross-sectional study was carried out at the Department of Male Reproduction, Reproductive Medical Center, the Second Hospital of Jilin University. The restriction fragment length polymorphism (RFLP) technique was used to detect gene point mutations. Of the 145 semen samples analyzed, 35 were asthenozoospermic, 50 were oligoasthenozoospermic, 21 were azoospermic, 11 w

SUBMITTER: Li D 

PROVIDER: S-EPMC4306983 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature