Uncoupling lifespan and healthspan in Caenorhabditis elegans longevity mutants.

ABSTRACT: Aging research has been very successful at identifying signaling pathways and evolutionarily conserved genes that extend lifespan with the assumption that an increase in lifespan will also increase healthspan. However, it is largely unknown whether we are extending the healthy time of life or simply prolonging a period of frailty with increased incidence of age-associated diseases. Here we use Caenorhabditis elegans, one of the premiere systems for lifespan studies, to determine whether lifespan and healthspan are intrinsically correlated. We conducted multiple cellular and organismal assays on wild type as well as four long-lived mutants (insulin/insulin-like growth factor-1, dietary restriction, protein translation, mitochondrial signaling) in a longitudinal manner to determine the healt

SUBMITTER: Bansal A 

PROVIDER: S-EPMC4311797 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature