Age-dependent changes in health status in the Childhood Cancer Survivor cohort.

ABSTRACT:

Purpose

To compare age-dependent changes in health status among childhood cancer survivors and a sibling cohort.

Methods

Adult survivors of childhood cancer and siblings, all participants of the Childhood Cancer Survivor Study, completed three surveys assessing health status. At each of three time points, participants were classified as having poor outcomes in general health, mental health, function, or daily activities if they indicated moderate to extreme impairment. Generalized linear mixed models were used to compare survivors with siblings for each outcome as a function of age and to identify host- and treatment-related factors associated with age-dependent worsening health status.

Results

Adverse health status outcomes were more frequent among survivors than sib

SUBMITTER: Hudson MM 

PROVIDER: S-EPMC4314595 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature