NeuroX, a fast and efficient genotyping platform for investigation of neurodegenerative diseases.

ABSTRACT: Our objective was to design a genotyping platform that would allow rapid genetic characterization of samples in the context of genetic mutations and risk factors associated with common neurodegenerative diseases. The platform needed to be relatively affordable, rapid to deploy, and use a common and accessible technology. Central to this project, we wanted to make the content of the platform open to any investigator without restriction. In designing this array we prioritized a number of types of genetic variability for inclusion, such as known risk alleles, disease-causing mutations, putative risk alleles, and other functionally important variants. The array was primarily designed to allow rapid screening of samples for disease-causing mutations and large population studies of risk factors.

SUBMITTER: Nalls MA 

PROVIDER: S-EPMC4317375 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature