The effect of skin fatty acids on Staphylococcus aureus.
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ABSTRACT:
SUBMITTER: Neumann Y
PROVIDER: S-EPMC4326651 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Publications
The effect of skin fatty acids on Staphylococcus aureus.
Neumann Yvonne Y Ohlsen Knut K Donat Stefanie S Engelmann Susanne S Kusch Harald H Albrecht Dirk D Cartron Michael M Hurd Alexander A Foster Simon J SJ
Archives of microbiology 20141018 2
Staphylococcus aureus is a commensal of the human nose and skin. Human skin fatty acids, in particular cis-6-hexadecenoic acid (C-6-H), have high antistaphylococcal activity and can inhibit virulence determinant production. Here, we show that sub-MIC levels of C-6-H result in induction of increased resistance. The mechanism(s) of C-6-H activity was investigated by combined transcriptome and proteome analyses. Proteome analysis demonstrated a pleiotropic effect of C-6-H on virulence determinant p ...[more]
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