Fasting hyperglycemia predicts lower rates of weight gain by increased energy expenditure and fat oxidation rate.

ABSTRACT:

Context

Increased adiposity and insulin resistance are associated with hyperglycemia and previous studies have reported that higher glucoses are associated with lower rates of weight gain. One possible mechanism is via increased energy expenditure (EE).

Objective

To assess the relationships between changes in EE during spontaneous weight gain and concomitant changes in glucose levels.

Design and participants

Body composition, metabolic, and glycemic data were available from nondiabetic Native Americans who underwent two measurements of 24-h EE during eucaloric feeding in a metabolic chamber (N = 144; time between measurements: 5.0 ± 3.3 years) or resting EE by ventilated hood system during the euglycemic-hyperinsulinemic clamp (N = 261; 4.5 ± 3.2 years). Long-term fol

SUBMITTER: Piaggi P 

PROVIDER: S-EPMC4333033 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature