Ability to adjust nocturnal fat oxidation in response to overfeeding predicts 5-year weight gain in adults.

ABSTRACT:

Objective

To determine whether metabolic responses to short-term overfeeding predict longitudinal changes in body weight.

Methods

Twenty-four-hour energy expenditure (EE) and substrate utilization were measured at baseline in a room calorimeter following 3 days of eucaloric and hypercaloric feeding (40% excess) in a sample of lean adults (n: 34; age: 28 ± 2 y; BMI: 22 ± 3 kg/m² ). Body mass and fat mass (dual-energy x-ray absorptiometry) were measured annually for 5 years. Regression analyses examined whether changes in EE and fuel use with overfeeding predicted body weight and composition changes over 5 years.

Results

Overfeeding increased EE and reduced fat oxidation when examined over the 24-hour, waking, and nocturnal periods. Absolute change in body ma

SUBMITTER: Rynders CA 

PROVIDER: S-EPMC5407418 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature